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中文简体1.Capsule design:
The design of enteric-coated hollow capsules is crucial for controlling drug release time. The shell of this capsule is usually made of a special material, the purpose of which is to ensure that the drug is not released prematurely in a highly acidic environment such as stomach acid, but only begins to dissolve after reaching the higher pH of the intestine. This is because many drugs are prone to failure or instability in acidic environments. Capsule shells are often made of materials that are enteric and insensitive to gastric acid, remaining intact in the stomach until entering the intestinal environment.
Capsule design can also affect release time. Some capsules may have complex construction, including tiny openings that allow the capsule to gradually dissolve in the stomach but not release the drug immediately. This design delays the release of the drug in the stomach until the capsule enters the intestinal environment.
2. Covering material:
The outer layer of enteric hollow capsules is generally made of enteric materials, such as methacrylate copolymer or sodium carboxymethyl cellulose. These materials do not dissolve in the acidic environment of stomach acid, but do dissolve in the higher pH intestinal environment, thereby promoting release of the drug in the intestine. This special material ensures that the capsule remains intact in the stomach and is not destroyed by gastric acid, and the drug is released only after entering the intestine.
The selection and use of enteric materials requires consideration of several factors, such as the material's effect on the drug itself, and its stability at a specific pH. The quality and characteristics of these materials will directly affect the release time and effectiveness of the drug.
3. Drug properties:
The characteristics of the drug itself are a key factor affecting the release time of enteric-coated hollow capsules. Some medications are prone to breakdown or failure in acidic environments and require enteric-coated capsules to protect them from exposure to the stomach. In addition, the solubility and chemical properties of the drug also affect its release rate in the intestine. Some medications may take longer to be fully released, while others may need to be released more quickly to achieve a therapeutic effect.
The properties of the drug are crucial to the design of enteric-coated hollow capsules. Proper enteric capsule design can ensure that the drug is released under optimal conditions and achieves therapeutic effects within the required time.
4. Thickness and structure of capsule wall:
The capsule wall design of enteric-coated hollow capsules is also one of the key factors in controlling release time. The thickness and configuration of the capsule wall can alter the rate of drug release in the intestine. Thicker walls may delay drug release because it takes longer to completely dissolve. In addition, different wall structures also have an impact on the release rate. Some capsules may have a layered wall structure, with different layers of material dissolving at different rates at different pH environments, thereby controlling release time.
Enteric-coated Hollow Capsules
Enteric-coated Hollow Capsules
Product introduction: Enteric gelatin hollow capsules are made of gelatin and enteric coating materials.
Product Category: Pharmaceutical Excipients
Product application: It is often used in special packaging for drugs or health care products that are irritating to the stomach or are unstable in the presence of acid, and that need to be dissolved in the intestine and exert their curative effect.
Product function: Intestinal positioning administration, reducing adverse reactions. Targeted fixed-point release: no disintegration and no cracks in gastric juice for two hours, and drug release in intestinal juice within 30 minutes, providing a perfect solution for protein polypeptide drugs and live bacteria preparations.
Product advantages: Intestinal-targeted drug delivery can improve drug efficacy and reduce dosage, and at the same time, it can reduce adverse reactions and facilitate the use of patients; it can also avoid the degradation of oral protein polypeptide drugs or health care products, providing the best absorption site for drugs.
