1. Humidity control: Humidity has an important impact on the stability of the drug and the performance of HPMC hollow capsules. One of the design features of HPMC capsules is their low hygroscopicity, which helps reduce the risk of drug degradation. To ensure the best results, the humidity of the production and storage environment should be maintained at an appropriate level. Ideally, the relative humidity should be controlled between 40% and 60% to avoid excessive moisture absorption by the capsule or filler, which would affect its physical and chemical properties. The use of sealed storage containers can further isolate humid air and ensure the long-term stability of the capsule and the drug. By regularly monitoring humidity and temperature, environmental conditions can be adjusted in time to ensure that product quality is not affected.

2. HPMC stability: The molecular structure of HPMC is very stable, which makes it less reactive in most active pharmaceutical ingredients (APIs). When selecting HPMC hollow capsules, it is crucial to understand the compatibility between the capsule material and the drug. By performing compatibility testing, it can be determined whether HPMC will react with a specific drug. Generally, HPMC does not contain protein, so it has less effect on the chemical properties of the drug. During the production process, ensuring the purity and quality of the capsule raw materials can effectively avoid potential chemical interactions, thereby ensuring the stability and efficacy of the drug.

3. Filling conditions: During the drug filling process, the use of gentle filling technology can effectively avoid damage to the HPMC hollow capsules while ensuring uniform distribution of the drug. Too fast or too strong filling actions may cause the capsules to rupture or deform, thereby affecting the release characteristics and dosage accuracy of the drug. It is recommended to use high-precision filling equipment and strictly control the speed and pressure during the filling process. Regular equipment maintenance and calibration can ensure the stability and consistency of the filling process, thereby ensuring the reliability of the filling effect.

4. Drug properties: Understanding the hygroscopic properties of the drug is the key to ensuring that the HPMC hollow capsule effectively protects the drug. For highly hygroscopic drugs, the low moisture absorption properties of HPMC capsules can prevent the drug from absorbing too much water inside the capsule, thereby maintaining the physicochemical properties and biological activity of the drug. When selecting fillers, it is also very important to understand the solubility and stability of the drug, which helps to develop a suitable filling strategy. Regular stability testing to evaluate the performance of the drug in HPMC capsules can ensure its safety and efficacy under different storage conditions.

5. Quality control: It is essential to implement strict quality control measures throughout the production process. This includes a comprehensive quality assessment of the HPMC capsules and filling process to ensure that there are no potential problems that affect the final product. Microbial limit testing and impurity testing can ensure that the drug and capsules are not contaminated during the production process. Regularly checking the quality of equipment and materials helps to ensure a clean and hygienic production environment. By establishing standard operating procedures (SOPs), ensure that each step has a standardized process, thereby improving the repeatability and reliability of production.

6. Proper storage: Storage conditions have a significant impact on the long-term stability of HPMC empty capsules and filled products. Capsules and finished products should be stored in a dry, cool place away from direct sunlight and high temperature environments. Using airtight storage containers can prevent moisture and contaminants from entering the air while maintaining the quality of capsules and drugs. Regularly checking storage conditions, including temperature and humidity, can detect potential problems in time and avoid affecting the quality of the product. Proper storage not only extends the shelf life of the product, but also ensures that the efficacy and safety of the drug are not affected.